This page reports published TxBench-Oligo-Discovery scores from benchmarks.bio. TxBench-Oligo-Discovery contains 113 evaluations built from real experimental data, each one graded deterministically against the biological result the original analysis reached, so a run counts as a pass only when the agent recovers that result rather than when it produces plausible-looking output. Results are reported per model and per harness rather than per model alone, because the harness an agent runs under changes its score substantially. Scores use a 0-100 percentage scale and are not comparable across benchmarks; see the linked repository and paper for task construction, grading, and confidence-interval methodology.
| Rank | Model | Harness | Provider | Score | Variant |
|---|---|---|---|---|---|
| 1 | Claude Opus 5.5* | Claude Code | Anthropic | 62.2% | LSVP |
| 2 | Claude Opus 5.5* | Pi | Anthropic | 59.9% | LSVP |
| 3 | Claude Fable 5.1* | Pi | Anthropic | 54.9% | LSVP |
| 4 | GPT-6.1 Sol | Pi | OpenAI | 52.5% | |
| 5 | Claude Sonnet 5.5 | Claude Code | Anthropic | 51.9% | |
| 6 | Claude Sonnet 5.5 | Pi | Anthropic | 51.9% | |
| 7 | GPT-6 Astra | Pi | OpenAI | 51.9% | |
| 8 | Gemini 4 Argon | Pi | 51.0% | ||
| 9 | GPT-6 Astra | Codex | OpenAI | 50.7% | |
| 10 | GPT-6.1 Sol | Codex | OpenAI | 49.6% | |
| 11 | Claude Opus 5 | Claude Code | Anthropic | 48.4% | |
| 12 | Grok 4.6 | Pi | SpaceXAI | 46.0% | |
| 13 | Grok 4.6 | Grok Build | SpaceXAI | 44.3% | |
| 14 | GPT-6 Sol | Pi | OpenAI | 43.1% | |
| 15 | Claude Opus 5 | Pi | Anthropic | 42.5% | |
| 16 | Grok 4.7 | Pi | SpaceXAI | 41.9% | |
| 17 | Gemini 3.7 Flash | Pi | 37.8% | ||
| 18 | Claude Opus 4.8 | Pi | Anthropic | 37.5% | |
| 19 | GPT-5.6 Sol | Codex | OpenAI | 37.2% | |
| 20 | Claude Sonnet 5 | Pi | Anthropic | 36.6% | |
| 21 | Claude Opus 4.8 | Claude Code | Anthropic | 36.0% | |
| 22 | GPT-5.6 Sol | Pi | OpenAI | 36.0% | |
| 23 | Gemini 3.8 Flash | Pi | 35.1% | ||
| 24 | DeepSeek V4.1 Flash | Pi | DeepSeek | 34.8% | |
| 25 | Claude Sonnet 5 | Claude Code | Anthropic | 33.9% | |
| 26 | GPT-5.5 | Pi | OpenAI | 33.9% | |
| 27 | GPT-6 Luna | Pi | OpenAI | 33.6% | |
| 28 | Claude Opus 4.7 | Pi | Anthropic | 31.9% | |
| 29 | GLM 5.3 | Pi | Z.ai | 31.9% | |
| 30 | Claude Opus 4.7 | Claude Code | Anthropic | 31.3% | |
| 31 | Kimi K3 | Pi | Moonshot | 31.3% | |
| 32 | GPT-6.1 Terra | Pi | OpenAI | 30.4% | |
| 33 | Claude Sonnet 4.6 | Pi | Anthropic | 30.1% | |
| 34 | GPT-6.1 Terra | Codex | OpenAI | 28.3% | |
| 35 | Claude Sonnet 4.6 | Claude Code | Anthropic | 28.0% | |
| 36 | Beam 1.0 | Pi | Reflection | 27.4% | |
| 37 | Mistral Large 4.0 | Pi | Mistral | 27.1% | |
| 38 | Nemotron 3 Ultra 550B A55B | Pi | NVIDIA | 25.1% | |
| 39 | GPT-5.6 Luna | Codex | OpenAI | 23.0% | |
| 40 | GPT-5.6 Luna | Pi | OpenAI | 23.0% | |
| 41 | Nemotron 3.5 Lightning | Pi | NVIDIA | 8.6% | |
| 42 | Claude Opus 5.5 | Pi | Anthropic | 1.5% | |
| 43 | Claude Opus 5.5 | Claude Code | Anthropic | 1.2% |
Methodology and provenance
Scores use a 0–100 percentage scale. See Paper PDF, Original publication, Repository for task construction, grading, aggregation, and uncertainty details.
LSVP: Anthropic's safety-filter-exempt evaluation variant, which produces fewer refusals on biology prompts. LSVP results are reported alongside the model's standard run and are not a replacement for it.