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# VariantBench results

> Agentic genetic variant discovery and interpretation tasks grounded in real biological analyses.

Data updated: 2026-09-20

Artifact generated: 2026-09-21T21:43:49.599Z

- Domain: Omics
- Horizon: short
- Assessment: Capabilities
- Published score scope: Full benchmark (118 evaluations)

Scores use a 0–100 percentage scale. Consult the repository and paper for benchmark-specific task construction, grading, aggregation, and uncertainty methodology. Results compare model-and-harness combinations.

| Rank | Model | Harness | Provider | Score |
| ---: | --- | --- | --- | ---: |
| 1 | Claude Opus 5 | Claude Code | Anthropic | 49.7% |
| 2 | Claude Opus 5 | Pi | Anthropic | 49.4% |
| 3 | GPT-6 Astra | Codex | OpenAI | 48.6% |
| 4 | GPT-6 Astra | Pi | OpenAI | 47.7% |
| 5 | Grok 4.6 | Grok Build | SpaceXAI | 46.0% |
| 6 | Claude Opus 4.8 | Pi | Anthropic | 42.1% |
| 7 | GPT-5.6 Sol | Codex | OpenAI | 42.1% |
| 8 | GPT-5.6 Sol | Pi | OpenAI | 41.2% |
| 9 | Claude Opus 4.8 | Claude Code | Anthropic | 39.8% |
| 10 | Claude Sonnet 5 | Claude Code | Anthropic | 38.7% |
| 11 | GPT-5.6 Terra | Codex | OpenAI | 38.7% |
| 12 | Claude Sonnet 5 | Pi | Anthropic | 38.1% |
| 13 | Grok 4.6 | Pi | SpaceXAI | 38.1% |
| 14 | Grok 4.5 | Pi | SpaceXAI | 37.6% |
| 15 | Claude Opus 4.7 | Pi | Anthropic | 37.0% |
| 16 | Claude Opus 4.7 | Claude Code | Anthropic | 35.6% |
| 17 | Gemini 3.5 Flash | Pi | Google | 35.3% |
| 18 | GPT-5.6 Terra | Pi | OpenAI | 34.7% |
| 19 | Kimi K3 | Pi | Moonshot | 32.8% |
| 20 | GPT-5.6 Luna | Codex | OpenAI | 29.9% |
| 21 | GPT-5.5 | Pi | OpenAI | 29.7% |
| 22 | GPT-5.5 | Codex | OpenAI | 28.8% |
| 23 | GPT-5.6 Luna | Pi | OpenAI | 28.2% |

## Sources and downloads

- [Paper PDF](/papers/variantbench.pdf)
- [Original publication](https://latch.bio/variantbench)
- [Repository](https://github.com/latchbio/variantbench)
- [Interactive benchmark](https://benchmarks.bio/variant)
- [JSON](https://benchmarks.bio/benchmarks/variantbench/latest.json)
- [CSV](https://benchmarks.bio/benchmarks/variantbench/latest.csv)
- [V1 cross-benchmark leaderboard](https://benchmarks.bio/results/v1/)